SARS vaccines: where are we?
Identifieur interne : 001583 ( Main/Exploration ); précédent : 001582; suivant : 001584SARS vaccines: where are we?
Auteurs : Rachel L. Roper ; Kristina E. RehmSource :
- Expert Review of Vaccines [ 1476-0584 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Humains, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Vaccins atténués (génétique), Vaccins atténués (immunologie), Vaccins inactivés (génétique), Vaccins inactivés (immunologie), Vaccins sous-unitaires (génétique), Vaccins sous-unitaires (immunologie), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie), Vaccins à ADN (génétique), Vaccins à ADN (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- génétique : Vaccins antiviraux, Vaccins atténués, Vaccins inactivés, Vaccins sous-unitaires, Vaccins synthétiques, Vaccins à ADN, Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère, Vaccins antiviraux, Vaccins atténués, Vaccins inactivés, Vaccins sous-unitaires, Vaccins synthétiques, Vaccins à ADN, Virus du SRAS.
- Animaux, Humains, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Humans, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), Vaccines, Attenuated (genetics), Vaccines, Attenuated (immunology), Vaccines, DNA (genetics), Vaccines, DNA (immunology), Vaccines, Inactivated (genetics), Vaccines, Inactivated (immunology), Vaccines, Subunit (genetics), Vaccines, Subunit (immunology), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , genetics : Vaccines, Attenuated, Vaccines, DNA, Vaccines, Inactivated, Vaccines, Subunit, Vaccines, Synthetic, Viral Vaccines.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, Vaccines, Attenuated, Vaccines, DNA, Vaccines, Inactivated, Vaccines, Subunit, Vaccines, Synthetic, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Humans.
Abstract
In this review, the current state of vaccine development against human severe acute respiratory syndrome (SARS) coronavirus, focusing on recently published data is assessed. We discuss which strategies have been assessed immunologically and which have been evaluated in SARS coronavirus challenge models. We discuss inactivated vaccines, virally and bacterially vectored vaccines, recombinant protein and DNA vaccines, as well as the use of attenuated vaccines. Data regarding the correlates of protection, animal models and the available evidence regarding potential vaccine enhancement of SARS disease are discussed. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Current data suggest that intranasal vaccination may be crucial and that new or combination strategies may be required for good protective efficacy against SARS in humans.
Url:
DOI: 10.1586/erv.09.43
PubMed: 19538115
PubMed Central: 7105754
Affiliations:
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Le document en format XML
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Roper</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Rehm, Kristina E" sort="Rehm, Kristina E" uniqKey="Rehm K" first="Kristina E" last="Rehm">Kristina E. 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We discuss which strategies have been assessed immunologically and which have been evaluated in SARS coronavirus challenge models. We discuss inactivated vaccines, virally and bacterially vectored vaccines, recombinant protein and DNA vaccines, as well as the use of attenuated vaccines. Data regarding the correlates of protection, animal models and the available evidence regarding potential vaccine enhancement of SARS disease are discussed. While there is much evidence that various vaccine strategies against SARS are safe and immunogenic, vaccinated animals still display significant disease upon challenge. Current data suggest that intranasal vaccination may be crucial and that new or combination strategies may be required for good protective efficacy against SARS in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Marra" uniqKey="Marra">Marra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota" uniqKey="Rota">Rota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier" uniqKey="Fouchier">Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng" uniqKey="Zheng">Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fleck" uniqKey="Fleck">Fleck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan" uniqKey="Guan">Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Che" 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uniqKey="Tan">Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo" uniqKey="Woo">Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu" uniqKey="Liu">Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenough" uniqKey="Greenough">Greenough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui" uniqKey="Sui">Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traggiai" uniqKey="Traggiai">Traggiai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roper" uniqKey="Roper">Roper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fogg" uniqKey="Fogg">Fogg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Golden" uniqKey="Golden">Golden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu" uniqKey="Hu">Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang" uniqKey="Yang">Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu" uniqKey="Qiu">Qiu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Rehm, Kristina E" sort="Rehm, Kristina E" uniqKey="Rehm K" first="Kristina E" last="Rehm">Kristina E. 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